Furthermore, the studies revealed that RCS suppress cancer cells progression by decreasing the activation of 1,3-dioxo-1,2-dithiolane moiety of thiazole comprising 18-membered lactam ring of leinamycin (LNM) antibiotics; via activation of mitochondrial apoptosis pathway; or by inhibition of expression and activities of lipoxygenase (LOX), cytochrome P450 (CYP) and cyclooxygenase (COX) [100,101,102]. The gene discussed is PPIG; the disease is cancer.