4-Hydroxy 2-nonenal (HNE) is reported for its implication in the tissue damage, aging associated injury, and other pathological conditions like cancer, inflammatory complications, diabetes, multiple sclerosis, AD and CVD [128,129], so oxidation of HNE by CYP subfamilies CYP4A and CYP3A highlights the importance of CYP450 enzyme as a therapeutic target for the treatment of various chronic diseases. Here, PPIG is linked to cancer.