ALDH2 and breast carcinoma: For example: the level of ALDH3A (the HNE inhibitor) may be enhanced in human breast carcinoma cell lines by treatment with 3-methylcholanthrene via activation of XRE [136]; ALDH3A2 (the fatty ALDH) may be enhanced using bezafibrate via peroxisome proliferator activated receptor α-dependent mechanism; ALDH2 (the inhibitor of hypertension, myocardial infarction and AD) can be enhanced by sulphorophane; ALDH1A3 and ALDH2 may be enhanced by butylated hydroxyanisole (BHA) via ARE/Nrf2 mechanism [9].