For instance, it has recently been shown that under conditions of bacterial sepsis, the extracellular form of the murine and human miR-130b-3p is released into the blood and interacts, thereby attenuating the pro-inflammatory function of CIRP (cold-inducible RNA binding protein), a ligand of TLR4-mediated innate inflammatory signaling [62,63]. This evidence concerns the gene TLR4 and bacterial infectious disease with sepsis.