TLR4 and infection: Although Toll signaling appears to be uninvolved in gut immunity and is rather confined to hemocyte and fat body during systemic infection [101], it has been recently shown that the interplay between microbiota-derived peptidoglycan (translocated from gut lumen into systemic circulation) and constitutive Toll pathway activation in Klf15 mutants lacking nephrocytes-cells and renal filtration of microbiota-derived peptidoglycan promotes resistance to infection [102].