The PI3K pathway is also dysregulated through other mechanisms including loss or inactivation of phosphatase and tensin homolog on chromosome 10 (PTEN), a tumor suppressor, and upregulation of tyrosine kinase growth factor receptors (RTKs) and oncogenes such as ras [6,7,26,27,28,29]. The gene discussed is PIK3CG; the disease is neoplasm.