Moreover, we found a strong correlation between the expression of HLA-A and IDH1wt in the TCGA dataset (Figure S7D), similar to the one observed between MAPT/Tau and IDH1. Taken together, our results suggest that the balance between mutant and wild-type IDH function in gliomas is controlling the expression of Tau, and probably other proteins, to shape the vascular and the immune niche of gliomas. This evidence concerns the gene MAPT and central nervous system cancer.