IDH2 and central nervous system cancer: Moreover, we found a strong correlation between the expression of HLA-A and IDH1wt in the TCGA dataset (Figure S7D), similar to the one observed between MAPT/Tau and IDH1. Taken together, our results suggest that the balance between mutant and wild-type IDH function in gliomas is controlling the expression of Tau, and probably other proteins, to shape the vascular and the immune niche of gliomas.