SNCA and Parkinson disease: Some mutant forms of α-synuclein that are linked to familial cases of PD (p.A30P and p.A53T) are not efficiently degraded through CMA; these mutant α-synucleins can bind LAMP-2A on the lysosomal surface with high affinity but are not internalized inside the lysosomes, preventing its own degradation and furthermore blocking CMA-dependent degradation of other substrates [57,58,62,63].