Interestingly, PD-linked disease mutations are found in the amphipathic region, and it is known that sphingolipid metabolites that accumulate in LSDs can interact with α-synuclein and induce its aggregation, which suggests that the interaction between α-synuclein and lipids plays an important role in PD pathogenesis and partially explains the selectivity of α-synuclein aggregation when lipid degradation is altered [28,47,48]. This evidence concerns the gene SNCA and Parkinson disease.