Two variants of WIPI4 (c.439 + 1G > T and c.1033_1034dupAA) were identified in patients with beta-propeller protein-associated neurodegeneration [98], while a third one is specifically linked to developmental and epileptic encephalopathy in patients with the same neurological disorder [341]. The gene discussed is WDR45; the disease is Epileptic encephalopathy.