Other examples of less-common risk alleles are those of SQSTM1 associated with frontotemporal dementia (c.1142C>T, K341V and K344E) [202,344] or muscle disorders such as sporadic inclusion body myositis (G194R) [204] and distal myopathies with rimmed vacuoles (p.G351_P388del and p.Glu389delinsAspLysTer) [345]. Here, SQSTM1 is linked to distal myopathy.