A study by Boughton et al. [56] describes forty-two patients with chronic lymphocytic leukemia (CLL), serum IgG levels < 5.5 g/L and a history of two or more recent infections, were randomized to receive infusions of 18 g human intravenous immunoglobulin (IVIg) or human albumin placebo every three weeks. Here, ALB is linked to B-cell chronic lymphocytic leukemia.