Intraperitoneal injection of Poly(I:C) one day before irradiation of LLC-OVA tumor enhanced the tumor shrinkage and, by the use of TLR3- and TICAM-1-deficient mice, the authors demonstrated that the effect was dependent on the activation of TLR3-TICAM-1 pathway [65]. Here, TICAM1 is linked to neoplasm.