MAPT and Alzheimer disease: As synaptic dysfunctions caused by tau oligomers are thought to precede neuronal loss in AD models [8], and decreased cerebral glucose metabolism relates to reduced synaptic activity [20, 21], we hypothesized that the association between t-tau-related cortical thinning and memory loss would be mediated, at least partially, by t-tau, cortical FDG uptake and/or by the serial relationship between t-tau and cortical FDG uptake.