Interestingly, only cb δ KO females spent less time in the center (control: 10.7% ± 0.9%, n = 32; cb δ KO: 7.7% ± 1.1%, n = 21; p < 0.032; Figure S4E) but not males (control: 8.0% ± 1.1%, n = 9; cb δ KO: 7.6% ± 1.6%, n = 9; p > 0.9; Figure S4F).The light/dark and open field tests suggest that especially female cb δ KO mice display increased anxiety-like behavior compared with control mice. The gene discussed is OPN1MW; the disease is Anxiety.