Although the prodomain of BMP family proteins has been shown to play a role in the proper folding and activity of the BMP domain (Neugebauer et al., 2015), the GDF6 prodomain without the BMP domain was sufficient to rescue growth arrest by GDF6 silencing (Figures 2F-2H), indicating the critical role of the BMP-independent prodomain function in Ewing sarcoma. This evidence concerns the gene GDF6 and Ewing sarcoma.