KCNH2 and torsades de pointes: Redfern et al. developed the following hERG SI based on potency, clinical PK data (including the highest reported Cmax), and reported TdP cases for 100 marketed drugs (including anti-arrhythmic hERG blockers), ranging from no reported cases to TdP-linked withdrawals [16]:UppersafehumanTFPCmax≤130invitrohERGIC50(1)