The comparison of patients that progressed or not to CKD-KRT (Table 5) revealed that most of the individuals in the first group were males (63.8% vs. 36.5%, p = 0.01), younger (30 vs. 34 years of age, p = 0.04), had hypertension (86.1% vs. 56.1%, p = 0.0016), worse creatinine levels at the biopsy time (3 vs. 1.2mg/dL, p<0.0001), lower eGFR (22.5 vs. 64.8ml/min/1.73m2, p<0.0001), and more frequent low serum C3 (25.7% vs 7,3%, p = 0.01), without difference in proteinuria. This evidence concerns the gene C3 and chronic kidney disease.