In addition to LPS, the rs12553564 variant was found to be an eQTL for IFNB1 in monocytes activated by Pam3CSK4 (targeting the TLR1/TLR2 receptors) and R848 (targeting the TLR7/TLR8 receptors), but not after infection with an influenza virus (S3B Fig). The gene discussed is TLR7; the disease is infection.