Adjusted rate ratios for the composite of CV death, MI, or stroke were 1.55 (95% confidence interval [CI], 1.27‐1.89) for the comparison between DM and non‐DM, 1.41 (95% CI, 1.12‐1.78) for the comparison between noninsulin‐treated DM and non‐DM, and 1.83 (95% CI, 1.39‐2.39) for the comparison between insulin‐treated DM and non‐DM (Table 4). This evidence concerns the gene INS and diabetes mellitus.