In HR-negative subgroup, pre-invasive carcinoma did not show a difference in TIL subset and PD-L1+ IC infiltration in relation to S100A8+ IC, whereas invasive carcinoma revealed significant higher TIL and PD-L1+ IC infiltration in S100A8+ IC (+) group compared to S100A8+ IC (−) group. This evidence concerns the gene S100A8 and invasive carcinoma.