MKI67 and invasive carcinoma: In pre-invasive carcinoma, the presence of S100A8+ TCs was associated with aggressive clinicopathologic features of tumor including a large extent of tumor, high nuclear grade, comedo-type necrosis, ER negativity, PR negativity, positive HER2 status, high Ki-67 index, and p53 overexpression (all p < 0.05).