S100A8 and invasive carcinoma: In invasive carcinoma, infiltration of S100A8+ IC showed a weak positive correlation with infiltration of CD4+ TIL (rho = 0.263) and a moderate positive correlation with infiltration of CD8+ and FOXP3+ TIL and PD-L1+ IC (rho = 0.474, 0.482 and 0.525, respectively, Supplementary Table S3).