S100A8 and invasive carcinoma: The proportion of S100A8+ TCs did not differ between pre-invasive and invasive carcinomas in the whole group (p = 0.544) and in the HR-positive subgroup (p = 0.228); however, it tended to be higher in invasive carcinomas than in pre-invasive carcinomas in the HR-negative subgroup (p = 0.081).