We may postulate that in BI-ALCL pathogenesis, the implant may have elicited a Th2-type response with accumulation of T cells, mast cells, monocytes and eosinophils and that, also consequently to the activation of the STAT3 pathway, IL-10-producing Tregs may eventually be recruited or induced as a feedback mechanism. This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.