CD4 and neoplasm: To support the assumption that BI-ALCL xenograft retained the immunophenotype of BI-ALCL seroma upon adaptation to the host environment, we immunostained the seroma and the related xenograft for CD30, CD3, CD4, GATA3 and FOXP3 (Fig. 7), which revealed expression of CD4, GATA3 and FOXP3 in a proportion of CD30-positive tumor cells in both the samples with a lower number of FOXP3 + cells compared to GATA3 + cells.