Hybridization signals (brown dots) for IL-10 or IL-6 were found in the cytoplasm of CD30-positive cells in both the BI-ALCL seroma and in the BI-ALCL xenograft, which consisted of pleomorphic tumor cells with highly atypical nuclei and prominent nucleoli encircling central necrotic areas (Fig. 6). The gene discussed is TNFRSF8; the disease is neoplasm.