Because BI-ALCL are composed of a large number of tumor cells associated with a small proportion of reactive cells including macrophages, small lymphocytes and eosinophils, to further confirm the production of IL-10 and IL-6 by the BI-ALCL tumor cells, we performed in situ hybridization (ISH) for IL-10 and IL-6 mRNA and IHC for CD30 on paraffin cell blocks of a BI-ALCL seroma and of a primary cultured BI-ALCL xenografted onto an NGS mouse (Fig. 6). The gene discussed is IL10; the disease is anaplastic large cell lymphoma.