Altogether, the abundance of IL-10, IL-13, IL-9, Eotaxin, Rantes and TNF-α and the frequent expression of GATA3 and FoxP3 transcription factors by neoplastic cells suggest that in BI-ALCL, a skewing towards Th2 and Treg cells occurs. The gene discussed is TNF; the disease is anaplastic large cell lymphoma.