CDC25A and esophageal squamous cell carcinoma: For example, miR-21 was highly expression in exosomes in ESCA, and anti-miR-21 inhibited the chemotherapy resistance of ESCA in vitro [37]; exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma [38].