TGF-β1 derived from platelets diminishes NK granule mobilization, cytotoxicity and INF-γ secretion [75] and induced an EMT (epithelial to mesenchymal transition) in carcinoma cells [68] TGF-β1 activity is associated with cancer stages, and microenvironment, and can have the opposite effect. Here, TGFB1 is linked to cancer.