Minocycline leads to improved outcomes in a mouse model of atherosclerosis (Shahzad et al., 2011), the transgenic APP/presenilin mouse model of Alzheimer's disease (Biscaro et al., 2012), the MPTP mouse model of Parkinson disease (Du et al., 2001) and after whole‐body γ‐irradiation in mice (Mehrotra et al., 2013) to name a few. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.