It was reported that NLRP3 transcription is tightly regulated by miR‐223‐3p through an evolutionarily conserved binding interaction between the 3′‐UTR of the NLRP3 mRNA and miR‐223‐3p in macrophages and hepatocellular carcinoma (HCC) cells. This evidence concerns the gene NLRP3 and hepatocellular carcinoma.