CRC‐derived EVs are enriched in microRNA‐21 and uptake of such EVs directs liver macrophages towards an interleukin‐6‐secreting phenotype through TLR7 pathways while silencing microRNA‐21 in CRC‐derived EVs or downregulation of TLR7 in liver macrophages ablates the pro‐inflammatory induction of liver macrophages. Here, TLR7 is linked to colorectal carcinoma.