PDCD4 and lung adenocarcinoma: Known to be crucial in metastasis‐associated osteolysis,71 osteoclastogenesis is found to be mediated by tumour‐derived EVs from lung adenocarcinoma cells by Xu et al.72EVs from lung adenocarcinoma cells contain high levels of microRNA‐21 which can be transferred to osteoclast progenitor via EVs, and promote osteoclastogenesis by targeting Pdcd4.