TheVWFitself harbors both a large number ofbona fidemutations and a common haplotype containing SNVs c.2365A > G and c.2385T > C affecting VWF biosynthesis and clearance.2, 17The rs1063857 (c.2385T > C) variant analyzed in this study and the rs1063856 (c.2365A > G) are reported to be in strong linkage disequilibrium and influence VWF levels independently.17The low VWF allele of rs1063857 was enriched in our VWD population by approximately 5% compared to all three control populations, which is in agreement with previous reports. Here, VWF is linked to von Willebrand disease (hereditary or acquired).