The coding sequences ofABO,VWF,STXBP5,STAB2,SCARA5,STX2,TC2N, andCLEC4Mwere screened for common and rare genetic variants by Ion Torrent sequencing of 104 patients from the historic VWD population. The gene discussed is STXBP5; the disease is von Willebrand disease (hereditary or acquired).