The previous observation showing non-apoptotic lamin fragmentation in the death process induced by Aβ peptide [4] was serendipitous, because caspase-6, implicated in neurodegenerative disease such as AD [23], is a well-known enzyme catalyzing the fragmentation of lamin proteins in processes induced by several different types of damaging agents [4]. Here, LMNA is linked to neurodegenerative disease.