CD8A and neoplasm: As shown in Fig. 4b, patients with CD8+PD-1+CD161− T cells enriched in tumor tissues had shorter recurrence-free survival (RFS, high vs. low = 28.7 months vs. 54.6 months, P = 0.0419) than patients with less CD8+PD-1+CD161− T cells, whereas no difference was observed for overall survival (OS) (Fig. 4b).