This conclusion is supported by the observation that YAP or TAZ knockdown obviously increased the accumulation of LC3B-II and ULK1, two well-established markers of autophagosome formation and autophagy induction; decreased the amount of SQSTM1/p62, a marker indicating low autophagic activity; and enhanced the formation of LC3B spots in RA-FLS, which are distributed on the autophagosome membrane. Here, SQSTM1 is linked to rheumatoid arthritis.