Our findings further confirmed that inhibition of autophagy by using 3-MA or CQ results in an increment of cell motility with the upregulation of N-cadherin and Vimentin and the reduction of the accumulation of E-cadherin and β-catenin in RA-FLS with stable knockdown of YAP or TAZ, suggesting that autophagy activation by YAP or TAZ knockdown acts to prevent EMT in RA-FLS. This evidence concerns the gene CDH1 and rheumatoid arthritis.