Thus, our study shed light on the specific role of ORMDL1 in different tumors via bioinformatics analysis, particularly in cholangiocarcinoma (CHOL), lymphoid neoplasm diffuse large B cell lymphoma (DLBCL), acute myeloid leukemia (LAML), and thymoma (THYM). The gene discussed is ORMDL1; the disease is cholangiocarcinoma.