Hence, mutation in many components of the Wnt signaling such as Fzd-441, LRP5/642, Norrin43, or APC44 result in defective retinal vasculogenesis leading to compensatory neovascularization, vascular leakage, retinopathy of prematurity, retinal detachment, or in certain cases retinal coloboma. This evidence concerns the gene LRP5 and Retinal coloboma.