GDF15 and Miyoshi myopathy: Corre et al. (J. [11]) reported that among several established prognostic factors (including staging according to the International Staging System—ISS), in multivariate analysis, GDF-15 remained the only significant predictor of event-free survival, while in vitro experiments showed pretreatment with GDF-15 leads to improved survival of both stroma-dependent and independent MM cells when exposed to staple drugs in the MM treatment armamentarium (i.e., melphalan, bortezomib, lenalidomide).