This point is of particular importance since in the Genotype-Tissue Expression Database [43], FERMT2 variants associated with an increase in AD risk at the genome-wide significance level are also part of an expression quantitative trait locus, significantly associated with decreased brain expression of FERMT2 mRNA (sentinel variant in GWAS rs17125924; −18%; p value = 2 × 10–6). Here, FERMT2 is linked to Alzheimer disease.