APP and Alzheimer disease: Recent high-throughput genomic approaches have also highlighted APP metabolism in the AD pathophysiological process: the main actors of APP metabolism, e.g., ADAM10 and APH1B (part of the γ-secretase complex), have been characterized as genetic determinants [11, 12], and numerous other genetic determinants have been described as potential modulators of APP metabolism (for a review, see ref. [13]).