Moreover, some studies even suggest that the increased expression of inflammation markers, including C-reactive protein, acute phase protein, soluble adhesion molecules, tumor necrosis factor, interleukin-1β (IL-1β), IL-6 and/or proinflammatory cytokines, in depressive individuals has become a distinctive clinical indicator of depression [175, 176, 178]. This evidence concerns the gene TNF and major depressive disorder.