The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (TOR) signalling pathway is known to suppress the activation of autophagy.77 Kim et al. found that the expression of Akt2 and the downstream targets of mTOR complex (mTORC)1, 4E-binding protein 1 (4EBP1) and 70-kDa ribosomal protein S6 kinase (p70S6K), was downregulated in glioma cells upon TTFields therapy, and that phosphorylation of mTOR at Ser2448 was reduced. The gene discussed is AKT1; the disease is central nervous system cancer.