GNE and exocrine pancreatic carcinoma: Using a combination of glycomic analysis with lectin-staining and cell studies, Amano et al.73 have shown that tumour suppressor p16(INK4a) modulates cell-surface sialylation and galectin expression to induce anoikis in human Capan-1 pancreatic carcinoma cells by downregulation of key enzymes involved in sialic acid biosynthesis, in particular the bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).