LGALS3 and neoplasm: They found that elevated ST6GalNAc II expression in oestrogen receptor (ER)-negative breast cancers impaired Gal-3 binding to the tumour cell surface, and correlated with reduced lung metastasis and improved survival.81 As sialylation was found to regulate Gal-3 binding, it was proposed that galectin inhibitors would be most effective for low ST6GalNAc II-expressing cells.