Overexpression of the sialyltransferase ST8Sia VI in its model decreased the survival time from greater than 6 months to 2–3 months.58 Further examples of immune evasion include upregulation of ST6Gal I and consequent α-2,6-sialylation in hepatocarcinoma cells, which was shown to inhibit the proliferation of T cells in the tumour microenvironment, thereby promoting immune evasion (Fig. 1).59 The gene discussed is ST6GAL1; the disease is neoplasm.