LGALS3 and neoplasm: Galectin-3 also plays a key role in tumour angiogenesis, migration and invasion,75 along with an emerging regulatory role in cancer stemness.76 However, Gal-3 has a broad spectrum of activity in tumour growth, where intracellular Gal-3 protects cells from apoptosis, while extracellular Gal-3 can induce apoptosis.