RHOT1 and cancer: Using a shRNA screen, Dario Altieri’s group demonstrated that many gene products linked to cytoskeletal trafficking in neurons (such as KIF5B, RHOT1 (miro), TRAK and SNPH) also participate in localising and concentrating mitochondria to the cell periphery of invading cancer cells—presumably to fuel the necessary energy demands.35 The same group has also identified and characterised mitochondrial proteins regulating cancer cell invasion/migration and metastasis, details of which can be found in refs. 36–38