Pro-survival proteins of the BCL-2 family prevent the accumulation of toxic Bax levels on the OMM by sequestering Bax.48 However, BCL-2 family members have been reported to have additional roles in invasion and migration.49,50 In addition to upregulating anti-apoptotic BCL-2 family proteins,51 tumour cells can evade apoptosis by limiting Bax access to OMM through mitochondrial hyperfragmentation.52 Subverting anoikis, the process by which epithelial cells die in response to lack of cell anchorage or anchorage to an unsuitable surface,53,54 is critical to metastasis. The gene discussed is BAX; the disease is neoplasm.