CD177 and central nervous system cancer: BCAR1 functions as an adaptor protein downstream of several cell-surface receptors including growth factor receptors and integrins.37 Activation of these cell-surface receptors induces phosphorylation of 15 tyrosine motifs (YxxP) of BCAR1 by SRC family kinases (SFKs).38 BCAR1 promotes EMT, cell motility, and invasion37 and is overexpressed in many human cancers including breast,39,40 glioma,38 prostate,41 ovarian,42 and hepatocellular carcinoma.43 The increased expression of BCAR1 in these cancers is frequently associated with advanced stage, metastatic properties, and poor survival rates.