Although the tumor growth rates did not differ in a statistically significant manner overall among the four groups (vehicle- versus AZD6738-treatment of POLD1+/+ versus POLD1R689W/- tumors), a discernible inhibition of tumor growth upon AZD6738 treatment was only observable in POLD1R689W/- tumors, while POLD1+/+ tumors displayed virtually identical tumor growth rates when compared to vehicle-treated animals. Here, POLD1 is linked to neoplasm.