14-3-3 proteins are implicated in CJD5, AD6, ALS7, PD8 and DLB9; α-synuclein is involved in AD10; and in synucleinopathies such as PD11, PDD12, PDM13 and DLB14; APOE is involved in AD15 and PD16; β-amyloid is involved in AD17 and DLB18; FUS is involved in Fronto Temporal Dementia (FTD)19 and ALS20,21 S100B is involved in AD22, FTD23 and ALS24; TARDBP/TDP-43 is involved in FTD, ALS25, AD26, DLB, PD and PDD27; τ is involved in tauopathies such as AD28, FTD and PDM29; in PD30, PDD and DLB31. The gene discussed is APOE; the disease is Parkinson disease.