This observation is likely due to high rates of SMARCA4 loss-of-heterozygosity (LOH) found in NSCLC (77%) and CUP (68%) patients, which frequently co-occur with KEAP1 or STK11 alterations (all three genes are found on the same LOH segment), accounting for the majority of homozygous SMARCA4 alterations. This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.