This observation is likely due to high rates of SMARCA4 loss-of-heterozygosity (LOH) found in NSCLC (77%) and CUP (68%) patients, which frequently co-occur with KEAP1 or STK11 alterations (all three genes are found on the same LOH segment), accounting for the majority of homozygous SMARCA4 alterations. Here, SMARCA4 is linked to non-small cell lung carcinoma.