Interestingly, homozygous SMARCA4 mutations were mutually exclusive with alterations in other BAF members (ARID1A, ARID1B, ARID2, PBRM1, SMARCB1 and SMARCD1) in NSCLC and CUP (Fig. 1d). Here, SMARCD1 is linked to non-small cell lung carcinoma.