In line with this, we show that some patient-derived PCa organoids that are classified as CRPC-NE using a transcriptome-based NEPC score4 (Supplementary Fig. 10), do not all show high expression of terminal neural markers such as synaptophysin, but instead may highly express factors related to “stemness” (e.g., SOX2). This evidence concerns the gene SOX2 and posterior cortical atrophy.