ACTL6B and prostate adenocarcinoma: In prostate adenocarcinoma cells, we observed that short-term REST knock-down led to an increase of BAF53B (ACTL6B) mRNA and protein levels, but the effect was modest, while other neuronal genes known to be negatively controlled by REST (e.g., synaptophysin) were highly upregulated (Supplementary Fig. 8).