SMARCA1 and neoplasm: We also noted intra-tumor heterogeneity in the expression of SWI/SNF subunits, as illustrated by IHC in patient specimens with a mixed phenotype (combining areas with adenocarcinoma and neuroendocrine differentiation) (Supplementary Figs. 4 and 5) and in 3D CRPC-NE organoid cultures (Supplementary Fig. 6).