Bulk RNA-seq data from 18 PCa organoids (CRPC-Adeno and CRPC-NE) (Supplementary Fig. 10) revealed that SMARCA4 expression was positively correlated with the expression of synaptophysin (a terminal neuronal marker), but also showed a tendency towards positive correlation with SOX2; conversely, there was a trend towards an inverse correlation between SMARCA2 and SOX2 (Pearson correlation analysis). Here, SMARCA4 is linked to posterior cortical atrophy.