One possible hypothesis is that an equivalent of the embryonic stem cell form of the complex (esBAF), which is known to exclusively incorporate BRG1 (SMARCA4), BAF53A and BAF155 (SMARCC1) subunits and not their paralogs18,19, could exist in cancers cells with pluripotent stem cell-like features, and possibly explain the overexpression and/or the functional requirement for these subunits. The gene discussed is SMARCA4; the disease is cancer.