We also noted intra-tumor heterogeneity in the expression of SWI/SNF subunits, as illustrated by IHC in patient specimens with a mixed phenotype (combining areas with adenocarcinoma and neuroendocrine differentiation) (Supplementary Figs. 4 and 5) and in 3D CRPC-NE organoid cultures (Supplementary Fig. 6). Here, SMARCA1 is linked to adenocarcinoma.