Among the genes most significantly deregulated upon SMARCA4 knock-down were several of known significance in PCa progression, including: upregulation of cell cycle regulators CDKN1A (p21) and BTG2 (in both LNCaP and 22Rv1 cell lines), downregulation of E2F targets (in both cell lines), downregulation of EZH2, and downregulation of the oncogenic long non-coding RNA PCAT-1 (both significant in LNCaP only)4,31,32 (Fig. 2c–e, Supplementary Fig. 12, Supplementary Data 5, Supplementary Data 6). Here, EZH2 is linked to posterior cortical atrophy.