Furthermore, a HFD induces ATMs from the M2-like phenotype (CD11c−CD206+) to the M1-like phenotype (CD11c+CD206−).4 However, in nude mice fed a HFD, adipocytes provide energy for the quick growth of metastatic cancer cells, which indicates that the suppression of the peritoneal seeding of CRC cells by HFD consumption relies on lymphocytes; that is, in mice with immune deficiency, high fat promotes PC progression, and in mice with normal immunity, high fat inhibits PC progression and prolongs survival. Here, ITGAX is linked to pachyonychia congenita.