MRC1 and pachyonychia congenita: Furthermore, a HFD induces ATMs from the M2-like phenotype (CD11c−CD206+) to the M1-like phenotype (CD11c+CD206−).4 However, in nude mice fed a HFD, adipocytes provide energy for the quick growth of metastatic cancer cells, which indicates that the suppression of the peritoneal seeding of CRC cells by HFD consumption relies on lymphocytes; that is, in mice with immune deficiency, high fat promotes PC progression, and in mice with normal immunity, high fat inhibits PC progression and prolongs survival.