CD4 and neoplasm: We first analyzed ChIP-Seq datasets for H3K27me3 in non-tumor breast cell line MCF10A (Fig. 5a and Supplementary Data 5a), prostate epithelial (PrEC) cell (Supplementary Fig. 9a and Supplementary Data 5b), CD4+ T cell (Supplementary Fig. 10a, Supplementary Data 1a), primary mammary epithelial (HMEC) cell (Supplementary Fig. 12a and Supplementary Data 5c), and human epidermal melanocytes (HEM) cell (Supplementary Fig. 14a and Supplementary Data 5d).