We performed several additional comparisons between cancer cells and matched non-cancer cells, including the leukemia cell Jurkat versus CD4+ T cell, breast cancer cell line MCF7 versus MCF10A, MDA-MB-231 versus HMEC, MCF7 versus HMEC, and melanoma cell SK-MEL-28 versus HEM (Supplementary Figs. 10–14). Here, CD4 is linked to breast cancer.