Kenji Kuba with colleagues from Penninger lab showed that the infection of mice with SARS-CoV resulted in decreased expression of ACE2 in the lung, dysregulation of renin–angiotensin system (RAS), leading to ALI.4 Thus, delivery of the soluble ACE2 has a potential to prevent or slow down the infection and to protect from ALI by increasing angiotensin-2 proteolysis. The gene discussed is REN; the disease is infection.