(2) The host factor eEF1A2 was found to be associated with HBV Pol, and the interaction of the two proteins was verified by a set of assays: Co-PI, yeast two-hybrid, GST pull-down, and confocal laser scanning microscopy; (3) Silencing of eEF1A2 gene by siRNA abrogated the HBV Pol-mediated anti-apoptotic effect in hepatoma cells, indicating the role for eEF1A2 in the HBV Pol-induced anti-apoptosis of hepatoma cells; (4) Bax is a water-soluble related protein homologous to Bcl-2. This evidence concerns the gene EEF1A2 and hepatocellular carcinoma.