MLL-induced AML may originate from hematopoietic stem cells (HSCs) and/or an early progenitor state and involve the establishment of leukemic stem cells (LSCs) that maintain lineage plasticity and an intermediate lymphoid–myeloid immunophenotype (Daigle et al, 2011; Goardon et al, 2011; Chen et al, 2013; Krivtsov et al, 2013). Here, KMT2A is linked to acute myeloid leukemia.