Knockout of GLTSCR1 in metastatic prostate cancer cell line PC3 resulted in a noticeable decrease in both colony formation and proliferation in this cell type, and similar effects were observed following GLTSCR1L knockout, suggesting a dependency of PC3 cells on GLTSCR1 and GLTSCR1L [27]. The gene discussed is BICRA; the disease is Familial prostate cancer.