SMARCB1 and T-cell non-Hodgkin lymphoma: Later, the tumor suppressor role was confirmed in mouse models [92–95] via conditional inactivation of Snf5, wherein around 15–30% of Snf5 heterozygous mice developed sarcomas similar to human MRTs, and biallelic inactivation of Snf5 caused fully penetrant T cell lymphoma to develop at a surprisingly rapid median onset of 11 weeks [95].