To further explore whether HOXA9/10 initiates enhancer-driven activation of global lnc-eRNA loci, we reanalyzed ChIP-seq data of HOXA9 [46] in MV4-11 cells and found that 16 of 18 i-BET-responding lnc-eRNA (Fig. 1b) loci exhibited HOXA9 enrichment (Fig. 5g and Additional file 4: Table S3), implying that most of these lnc-eRNAs could be activated via this HOXA initiation-BRD4 transcriptional activation mechanism and that modulating the expression of these lnc-eRNAs may be an alternative strategy to target the HOXA cluster [47] in MLL leukemia. The gene discussed is BRD4; the disease is leukemia.