Furthermore, Ma and colleagues [163] whilst working on SAH (subarachnoid haemorrhage)-induced early brain injury added that administration of rPK2 (recombinant PK2) or augmenting PK2 expression may stimulate a modulation of astrocytic polarisation towards a more protective (A2-type) phenotype. This evidence concerns the gene PROK2 and subarachnoid hemorrhage.