For instance, one study reported a PGS area under the curve of 0.57 for Alzheimer’s disease (parental proxy) using 21 SNPs and excluding the APOE region [7], while another study reported using more than 200,000 variants (including APOE) and a PGS area under the curve of 0.84 for Alzheimer’s disease [15]. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.