APOE and early-onset autosomal dominant Alzheimer disease: Both the Alzheimer’s disease PGS (without the APOE region) at pT = 0.001 and 0.01 were significantly associated with the odds of dementia (pT = 0.001 OR = 1.1 95%CI 1.0 to 1.2 and pT = 0.01 OR = 1.1 95%CI 1.0 to 1.2).