A genetic reduction of PCSK9 levels by 50% is associated with a similar percent reduction of coronary heart disease (CHD) risk [59] and a genetic large-scale study on 337,536 individuals of British ancestry reported that the rs11591147 PCSK9 mutation had a protective effect not only on hyperlipidemia, but also on the risk of CHD (− 27%) and ischemic stroke (− 39%) [60]. This evidence concerns the gene PCSK9 and hyperlipidemia.